Ivermectin is widely used in gastrointestinal nematodes, lung nematodes and parasitic arthropods of cattle, sheep, horses and pigs, intestinal nematodes of dogs, auricular mites, scabies, cardiofilariae and microfilariae, and gastrointestinal nematodes and ectoparasites of poultry.

Cattle, sheep ivermectin (l) according to the amount of 0.2 mg/kg to cattle, sheep or subcutaneous injections, take orally to nematodes, blood spear oster nematode, nematode, wool round worms cooper (including airy wool round worms), round worms, Yang mouth nematodes, thin neck nematode, nematode, MAO esophagus, net worm mouth nematodes and sheep chabert nematode worm and 4 larva, insect repellent rate of 97% ~ 100%.These doses are also effective on arthropods, such as fly maggots (bovine dermatodermata, oryzoma oryzae), mites (bovine scabies, oryzoma oryzae), and lice (bovine palatine lice, bovine blood lice, and sheep palatine lice).Ivermectin is less effective against chewing lice (Heteroptera) and sheep tick flies.

Ivermectin is also highly effective against ticks and flies that breed in feces. Although the drug does not kill or dismember ticks immediately, it can shadow them

Intake, molt, and lay eggs, thereby reducing reproductive capacity.Animals were given a subcutaneous injection of 0.2mg/kg once or fed at a low concentration daily

(0. 01mg/kg), the above phenomenon was most obvious at 5 days after treatment.According to 0.2 mg/kg dose a subcutaneous injection of breeding in the feces of flies also have certain control effect, cattle use 9 days after their faeces plane flies, autumn housefly larvae cannot develop adult, another 5 days, due to the deformity of pupa and adult mature process is inhibited, thus greatly reducing the flies breeding of blood fly (one blood fly) in the dose, similar after 4 weeks.

(2) Oral administration of 0.2mg/kg ivermectin was highly effective (95% ~ 100%) against the adults and the 4th stage larvae of the following genera, large and small round nematodes.For example, large round nematode (round nematode common, round nematode equine, round nematode odontodon), roundworm (parasascaris equis), pinworm (equisetail nematode), stomach worm (dractomiasis largemoritis, soft line nematode), small intestine nematode (dractomiasis erichoi, round nematode westeri), lung nematode (reticulocyta andersonii), etc.For the three species of horse gastrofly maggots in the transitional or gastric residence period, the microfilariae of the oncoparasite that causes skin damage, and the third stage larvae of the gastric nematode, the best treatment is to give the same amount again after one month, although the dose of 0.2 mg/kg is also limited.

Of particular significance, the recommended dose of ivermectin (0.2mg/kg) was effective in treating mesenteric artery damage during the transitional phase for early and stage 4 larvae of C. common. Symptomatic relief was usually evident after 2 days of treatment, and all of the damage disappeared in about 28 days.

(3) Intramuscular injection of 0.3mg/kg ivermectin showed broad spectrum insecticidal activity in pigs.For example, the removal rate of adult and immature worms such as ascaris porcis, Strongonematode red, Strongonematode orchid, Trichoderma sinifera, esophagostomatode, Strongonematode hindus, Coronodentata was 94% ~ 100%, and it was also very effective against trichinella trichinella in the intestine (no effect in the muscle).The above methods also had good control effect on pig blood louse and sarcoptic mite.

(4) Dogs and cats have special dosage forms (according to the amount of 6 ~ 12μg/kg) for the prevention and treatment of microfilariae infection in dogs, China can try 50μg/kg internal treatment of microfilariae infection in dogs (adult worm ineffective).Clinical trials have confirmed that high doses of ivermectin are effective against various canine parasites. For example, a single subcutaneous injection of 50μg/kg against Uncinostomia Canis, Uncinostomia brazilensis, and Uncinostomia Canis, 100μg/kg against Trichoderma Canis, and 200μg/kg against Toxocaris Canis adults and the fourth stage larval, all have excellent insecticidal effect.At 200μg/kg dose, the efficacy of subcutaneous injection was only 69%, while that of internal administration was 95%.A single subcutaneous injection of this product can be used to treat the lung parasitic nematode (200μg/kg) and nematode (400μg/kg) of dogs.

Also has the excellent expelling effect.Intravenous or subcutaneous injection of 200μg/kg, two weeks after the use of again, intestinal Strongymoides (No

Except for stage 3 larvae) the effective rate is 95% ~ 100%.

Ivermectin is also effective against some arthropod infections in dogs and cats, given subcutaneously at a dose of 200μg/kg for two weeks

The infection of auricular mite, sarcoptic mite and canine pulmonary mite can be eliminated by a second dose.300μg/kg, used twice (2 weeks interval)

It is also very effective against chelchelate mite infection.Demodex canine is best treated by subcutaneous injection of 600μg/kg at an interval of 7 days.Use it five times.

(5) Birds are highly effective against domestic nematodes such as Acaris chinensis and Trichoderma occlusion, as well as domestic parasitic arthropods such as Tetracarpa geniculata (Tetracarpa geniculata), which can be taken orally or injected subcutaneously at a dose of 200 ~ 300μg/kg.However, this product has no effect on chicken anisocystis nematode.

(6) The infection of Oedemagena tarandi by caribou was subcutaneously injected at the dosage of 200μg/kg of caribou.